Discover the top 10 cities where physician assistants thrive in 2025! With PA jobs ranked #2 in healthcare and #4 overall by U.S. News, these professionals enjoy median salaries of $130,020+ and 28% projected growth. Find out which cities offer the best balance of high salaries, job availability, and affordable housing—from Baltimore’s exceptional 53% salary-to-home price ratio to Hartford’s overall winning combination.